Hyaluronidase: from clinical applications to molecular and cellular mechanisms

Hyaluronidase: from clinical applications to molecular and cellular mechanisms.

Over the past 60 years, hyaluronidase has been successfully utilized in ophthalmic surgery and is now being implemented in dermatosurgery as well as in other surgical disciplines. The enzyme is considered a "spreading factor" as it decomplexes hyaluronic acid (also called hyaluronan, HA), an essential component of the extracellular matrix (ECM). When applied as an adjuvant, hyaluronidase enhanc...

Postischemic revascularization: from cellular and molecular mechanisms to clinical applications.

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular, cellular, and extracellular responses that determine the function and the remodeling of the ischemic tissue. Hypoxia-related pathways, immunoinflammatory balance, circulating or local vascular progenitor cells, as well as changes in hemodynamical forces within vascular wall trigger all the processes regu...

O14: Cellular and Molecular Mechanisms of Spinal Cord Trauma

لطفاً به چکیده انگلیسی مراجعه شود.

Three-dimensional cell cultures: from molecular mechanisms to clinical applications.

This article reviews actual advances in the development and application of three-dimensional (3-D) cell culture systems. Recent therapeutically oriented studies include characterization of multicellular-mediated drug resistance, novel ways of quantifying hypoxia, and new approaches to more efficient immunotherapy. Recent progress toward understanding the development of necrosis in tumor spheroi...

Optical Elastography: From Theory to Clinical Applications